Assessment of Vancomycin Penetration into Cerebrospinal Fluid in Patients with Ventriculitis Using a Physiologically Based Pharmacokinetic Approach
Vancomycin penetration into the CNS is low and variable, highlighting the importance of therapeutic drug monitoring and individualized therapy in patients with ventriculitis. In the future, this model may facilitate the selection of optimal dosing regimens by simulating alternative dosing strategies and establishing PK/PD relationships for CNS infections.
Authors
- Carolina Hikari Yamada (ORCID: https://orcid.org/0000-0002-0065-3963)
- Fernanda de Lima Moreira (ORCID: https://orcid.org/0000-0001-7699-2665)
- Felipe Francisco Tuon (ORCID: https://orcid.org/0000-0003-3471-1786)
- João Paulo Telles
- Jhohann Richard de Lima Benzi
- Larissa Martins Alves Guimarães
- Mayra Torres de Oliveira Santos
- Letícia Oliveira de Vasconcellos Nacif
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade de São Paulo (BR)
- AC Camargo Hospital (BR)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s11095-026-04023-5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior