Maternal nutrition alters mRNA isoform expression, usage, and splicing dynamics in skeletal muscle of beef cattle offspring
Overall, prenatal nutrition, particularly protein-energy supplementation throughout gestation in comparison to mineral supplementation, modulates offspring muscle mainly through transcript usage and splicing, suggesting long-term adaptive mechanisms beyond gene-level regulation.
Authors
- Guilherme Henrique Gebim Polizel (ORCID: https://orcid.org/0000-0002-8497-9898)
- José Bento Sterman Ferraz (ORCID: https://orcid.org/0000-0002-3874-3104)
- Aline Silva Mello César (ORCID: https://orcid.org/0000-0001-9921-214X)
- Miguel H A Santana
- Felipe Eguti de Carvalho (ORCID: https://orcid.org/0000-0002-7003-6709)
- Wellison J S Diniz
- Germán D. Ramírez-Zamudio
- Luiz F. Brito
- Heidge Fukumasu
- Ángela Cánovas
Institutions
- Livestock Improvement Corporation (NZ)
- Purdue University West Lafayette (US)
- Institute of Food Science and Technology (CN)
- Animal, Food and Health Sciences (AU)
- Auburn University (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fgene.2026.1734234
- Primary Topic
- Reproductive Physiology in Livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo