Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis

Consistent with the overall population, amivantamab-lazertinib significantly improved OS versus osimertinib among Asian participants with previously untreated EGFR-mutated advanced NSCLC, making it the first regimen to improve survival among Asian patients.

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Publication Details

Journal
Lung Cancer
Published
2026-02-04
DOI
https://doi.org/10.1016/j.lungcan.2026.109305
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis

Adlinda Alip, Alianu K. Akawung, E. Fennema, Yuta Yamanaka et al.
Lung Cancer
Lung Cancer Treatments and Mutations
article

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis

Adlinda Alip, Alianu K. Akawung, E. Fennema, Yuta Yamanaka, James Chih-Hsin Yang, Sujay Shah, Hidetoshi Hayashi, Koichi Azuma, Gee-Chen Chang, Hailin Xiong, Seema Sethi, Pongwut Danchaivijitr, Byoung Chul Cho, Xiaodan Tang, Shun Lu, Yu. Ya. Kim, Se-Hoon Lee, Kumar Prabhash, Mehmet Ali Nahit Şendur, Soon-Hin How
article en

Abstract

Consistent with the overall population, amivantamab-lazertinib significantly improved OS versus osimertinib among Asian participants with previously untreated EGFR-mutated advanced NSCLC, making it the first regimen to improve survival among Asian patients.

Lung CancerVol. 214
Kurume University (JP), Kansai Medical University (JP), Johnson & Johnson (United States) (US), Siriraj Hospital (TH), Yonsei University (KR), Tata Memorial Hospital (IN), Samsung Medical Center (KR), Shanghai Chest Hospital (CN), Seoul National University Bundang Hospital (KR), University of Malaya (MY), International Islamic University Malaysia (MY), Chung Shan Medical University Hospital (TW), Kindai University Sakai Hospital (JP), Johnson Electric (China) (CN), National Taiwan University Hospital (TW), Huizhou Central People's Hospital (CN), Ankara Yıldırım Beyazıt University (TR), Sungkyunkwan University (KR), Chung Shan Medical University (TW)
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Openalex Percentile: Top 68%
Lung Cancer Treatments and Mutations
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