Sex-based differences in 10-year outcomes and bioprosthetic durability after TAVR with self-expanding valve bio-prosthesis: insights from a multicenter cohort
Despite older age and increased procedural risk, female patients demonstrated more favorable long-term survival and similar valve durability compared to males over 10 years following TAVR with first-generation CoreValve/Evolut R prostheses. These findings underscore the long-term reliability of self-expanding valves and highlight the need for individualized, sex-specific strategies in TAVR patient selection and management.
Authors
- Erica Ferrara (ORCID: https://orcid.org/0000-0002-4659-441X)
- Ottavia Cozzi (ORCID: https://orcid.org/0000-0002-0700-1781)
- Giuliano Chizzola
- Marco Di Maio (ORCID: https://orcid.org/0000-0001-8665-9890)
- M Montorfano
- Cristina Giannini (ORCID: https://orcid.org/0000-0002-5472-6881)
- Riccardo Gorla (ORCID: https://orcid.org/0000-0003-4682-5289)
- Bárbara Bellini (ORCID: https://orcid.org/0000-0003-0187-065X)
- Tiziana Attisano (ORCID: https://orcid.org/0000-0002-2864-2756)
- Francesco Vigorito
- Adele Pierri
- G. Bruschi
- Marco Stefano Nazzaro
- Carmine Vecchione (ORCID: https://orcid.org/0000-0002-2473-4565)
- Mario Ferraioli (ORCID: https://orcid.org/0009-0006-4866-3710)
- Arnaldo Poli
- C Giulia
- Luca Testa
- Francesco Saia
- Gennaro Galasso
- M De Carlo
- Francesca Maria Di Muro
- Antongiulio Maione
- Bruno Merlanti
- Mauro Massussi
Institutions
- University of Salerno (IT)
- Vita-Salute San Raffaele University (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- IRCCS Policlinico San Donato (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Aziende Socio Sanitarie Territoriale Ovest Milanese
- University of Bologna (IT)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1007/s00392-026-02856-z
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Salerno