KIR AA individuals possess strong inhibitory KIR alleles alongside HLA ligands that are protective against leukemia in the Chinese population
These data suggest that <i>KIR AA</i> individuals possess strong inhibitory interactions of <i>KIR</i> alleles and <i>HLA</i>, arming <i>KIR AA</i> <sup><i>+</i></sup> NK cells to meditate stronger alloreactivity and cytotoxicity against leukemia cells with lowered HLA expression. Our findings may provide valuable insights into leukemia pathogenesis and better understanding of the immune mechanisms.
Authors
- Qiong Yu (ORCID: https://orcid.org/0000-0003-1143-1749)
- Shuang Liang (ORCID: https://orcid.org/0000-0003-1251-1732)
- J. Liu
- Zhihui Deng (ORCID: https://orcid.org/0000-0001-5545-8279)
- S. Cai
- Yunan Li
- Jinyong Wang
- Manru Zhang (ORCID: https://orcid.org/0009-0002-3459-222X)
- Renhui Jiang
- Jianxin Zhen
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Shenzhen Blood Center (CN)
- University of Chinese Academy of Sciences (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fgene.2025.1745482
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen