ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics

ISG15 in BRCA CSCs promotes lymph node metastasis by driving M2 macrophage polarization and suppressing T-cell activation, highlighting a critical role for ISG15-mediated immunomodulation and a potential therapeutic target.

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Publication Details

Journal
BMC Medicine
Published
2026-02-04
DOI
https://doi.org/10.1186/s12916-025-04614-w
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00
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article

ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics

Hua Shao, Hanlu Tang, Yongqing Xu, Huiying Lin
BMC Medicine
interferon and immune responses
article

ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics

Hua Shao, Hanlu Tang, Yongqing Xu, Huiying Lin
article en

Abstract

ISG15 in BRCA CSCs promotes lymph node metastasis by driving M2 macrophage polarization and suppressing T-cell activation, highlighting a critical role for ISG15-mediated immunomodulation and a potential therapeutic target.

BMC MedicineVol. 24(1)
China Medical University (CN)
Good health and well-being
Openalex Percentile: Top 66%
interferon and immune responses
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ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics — Hua Shao, Hanlu Tang, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS