Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy
A robust PBS proton-LRT planning approach was developed and compared to photon VMAT-LRT for large liver tumors. Our IMPT-LRT approach maximizes peak-to-valley separation and simultaneously maintains target coverage while significantly reducing valley dose, as compared to traditional VMAT-LRT. These findings support future prospective clinical evaluation.
Authors
- Gabriel O. Sawakuchi (ORCID: https://orcid.org/0000-0001-5560-0650)
- Christine Chung (ORCID: https://orcid.org/0000-0002-3093-6913)
- L Perles (ORCID: https://orcid.org/0000-0002-5326-1998)
- A. Brito Delgado (ORCID: https://orcid.org/0000-0003-0747-7672)
- Laurence E. Court (ORCID: https://orcid.org/0000-0002-3241-6145)
- Falk Poenisch
- Eugene H. Koay
- Jamie Baker (ORCID: https://orcid.org/0000-0002-0361-0379)
- Joshua S. Niedzielski (ORCID: https://orcid.org/0000-0002-7666-5039)
- Saurabh Sudhakaran Nair
- Yuting Li (ORCID: https://orcid.org/0000-0001-9719-649X)
- Zhu Rx
- Rachael M. Martin-Paulpeter
- Sam Beddar
- Ethan B. Ludmir
- Narayan Sahoo
- Miguel A. Aguilar
- David B. Flint
- Carlos A. Matias
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fonc.2025.1731259
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Heart, Lung, and Blood Institute
- National Cancer Institute