Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression

This study provides robust causal evidence linking lipid metabolism and ketone bodies to PCOS, moving beyond descriptive associations. by uncovering the specific pathway involving 3-HB and HDAC3, we highlight a novel molecular mechanism underlying PCOS pathogenesis. These findings suggest that targeting the 3-HB/HDAC3 axis could offer new strategies for therapeutic intervention in managing PCOS-related metabolic dysfunction.