Evidence Based on Sleep Disorder Exacerbating Postoperative Pain via Kynureninase
We conclude that the upregulated expression of KYNU is associated with the exacerbation of postoperative pain due to sleep deprivation and identified the compound carbidopa as possessing significant analgesic potential.
Authors
- Yongqin Chen
- Yuanjing Chen
- Xinqing Yang (ORCID: https://orcid.org/0009-0002-4098-8634)
- Chengkun Tao
- Guangyou Duan
- Bin Shu
- Niannian Huang
- Yi Yang
- Yifan Zhang
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/dddt.s565401
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00