Immunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion
We demonstrate that IgGs from ME/CFS patients carry a chronic protective stress response that promotes mitochondrial adaptation via fragmentation, without altering mitochondrial ATP generation capacity in endothelial cells. Together, these results highlight a potential pathogenic role of IgG in post-infectious ME/CFS and point to novel therapeutic strategies targeting antibody-mediated metabolic dysregulation.
Authors
- Franziska Sotzny (ORCID: https://orcid.org/0000-0003-1593-8563)
- Lība Sokolovska (ORCID: https://orcid.org/0000-0002-5820-1783)
- Andreas Schlösser (ORCID: https://orcid.org/0000-0003-0612-9932)
- Judith Bellmann–Strobl (ORCID: https://orcid.org/0000-0003-2615-1643)
- Bhupesh K. Prusty (ORCID: https://orcid.org/0000-0001-7051-4670)
- Sharada Kalanidhi
- Claudia Hollmann (ORCID: https://orcid.org/0000-0002-3933-8370)
- Stephanie Lamer
- Georgy Nikolayshvili
- Emils Edgars Basens
- Zheng Liu
- Rebekka Rust
- Gabriela Riemekasten
- Friedemann Paul
- Carmen Scheibenbogen
- Robert K. Naviaux
Institutions
- University of Würzburg (DE)
- University of California San Diego (US)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Schleswig-Holstein (DE)
- Riga Stradiņš University (LV)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
- Stanford University (US)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1016/j.bbih.2026.101187
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00