Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis–inflammatory bowel disease cohort
While some individuals with PSC-IBD experienced an extended event-free disease course, a large proportion experienced disease-related cancer, colectomy, cholecystectomy, and transplant events. Higher mortality rates observed after surgery were likely related to underlying disease processes that motivated surgical intervention (eg, dysplasia/malignancy, refractory IBD), rather than the surgery itself. Understanding how PSC-IBD disease trajectories vary can inform individual management and patient counselling.
Authors
- Bo Mølholm Hansen (ORCID: https://orcid.org/0000-0002-3087-3983)
- Aliya Gulamhusein (ORCID: https://orcid.org/0000-0003-4648-4736)
- Kristel Leung (ORCID: https://orcid.org/0000-0002-1161-4118)
- Lauren Lapointe‐Shaw (ORCID: https://orcid.org/0000-0003-4485-6719)
- Wenbin Li
- Gideon M. Hirschfield
- Jennifer A. Flemming
- Eric I. Benchimol
Institutions
- University of Toronto (CA)
- Queen's University (CA)
- Toronto General Hospital (CA)
- Erasmus MC (NL)
- Public Health Ontario (CA)
- SickKids Foundation (CA)
- Institute for Clinical Evaluative Sciences (CA)
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1097/hep.0000000000001692
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00