Research Progress on the Application and Mechanisms of Baihe Dihuang Decoction in Major Depressive Disorder

BHDH possesses a multi-target pharmacological basis for antidepressant activity. Existing clinical evidence supports its effectiveness and relative safety as an adjunctive therapy for MDD. To better define its clinical role and advance TCM modernization, future research should prioritize rigorous randomized controlled trials, elucidate its formula compatibility mechanisms, and identify its key bioactive components.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2026-02-01
DOI
https://doi.org/10.2147/dddt.s579207
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Research Progress on the Application and Mechanisms of Baihe Dihuang Decoction in Major Depressive Disorder

Hejia Wan, Y. Liu, Yi Tian Liu, Yanle Zhi et al.
Drug Design Development and Therapy
Tryptophan and brain disorders
article

Research Progress on the Application and Mechanisms of Baihe Dihuang Decoction in Major Depressive Disorder

Hejia Wan, Y. Liu, Yi Tian Liu, Yanle Zhi, Hao Feng, Yilong wang, Fengjiao Zhang, Longlong Yang, Zhiqiang Zhang, Guimin Xue
article en

Abstract

BHDH possesses a multi-target pharmacological basis for antidepressant activity. Existing clinical evidence supports its effectiveness and relative safety as an adjunctive therapy for MDD. To better define its clinical role and advance TCM modernization, future research should prioritize rigorous randomized controlled trials, elucidate its formula compatibility mechanisms, and identify its key bioactive components.

Drug Design Development and TherapyVol. Volume 20
Henan University of Traditional Chinese Medicine (CN), Henan University of Technology (CN), Henan Provincial People's Hospital (CN), First Affiliated Hospital of Henan University (CN), Henan Agricultural University (CN), Henan University of Economic and Law (CN)
China Postdoctoral Science Foundation, Natural Science Foundation of Henan Province
Good health and well-being
Openalex Percentile: Top 68%
Tryptophan and brain disorders
DOIOpen Access PDFOpenAlex
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