M2-sEVs-based immunotherapy for alleviation of osteoarthritis-related pain by regulating synovial macrophage NGF expression via the NOTCH pathway
M2-sEVs effectively reduce OA-related pain by suppressing macrophage-derived NGF expression via the Notch pathway, highlighting their promising potential as a nanomedicine-based therapeutic strategy for OA pain management.
Authors
- Feng Ke (ORCID: https://orcid.org/0000-0002-1906-9636)
- Luhao Sun (ORCID: https://orcid.org/0009-0005-2937-4019)
- Xuetao Xie
- Jiashuo Liu (ORCID: https://orcid.org/0000-0002-9659-6069)
- Q. Y. Li (ORCID: https://orcid.org/0009-0000-5868-2487)
- Yang Wang
- Yuhang Du
- Lei Luo
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Nanomedicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1080/17435889.2026.2623975
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00