Orexin dual receptor antagonist attenuates neurological deficits possibly via PI3K/Akt/mTOR pathway activation in sleep-deprived stroke rats
Almorexant was associated with attenuation of SD-exacerbated ischemic brain injury in rats, accompanied by alterations in PI3K/Akt/mTOR signaling, suggesting DORAs may have potential relevance for the management of post-stroke insomnia.
Authors
- Gang Li (ORCID: https://orcid.org/0000-0003-1957-471X)
- Haiyu Li (ORCID: https://orcid.org/0000-0002-2097-1061)
- Baofeng Wang
- Lili Wang
- Feifeng Liu
- Xinli Xiong
Institutions
- Tongji University (CN)
- Shanghai Medical College of Fudan University (CN)
- Ruijin Hospital (CN)
- Songjiang District Central Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111762
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00