Mapping the clinical correlates of brain hypoperfusion in behavioral variant frontotemporal dementia: insights from a SPECT imaging study

These findings reveal that distinct patterns of regional hypoperfusion are selectively linked to specific cognitive, behavioral, and personality alterations in early-stage bvFTD, highlighting the neural substrates underlying its core clinical features. Identifying discrete brain regions associated with key symptoms may inform the development of more targeted therapeutic interventions, ultimately enhancing personalized management and care for individuals affected by this complex and highly disabling syndrome.