ROOT EXTRACT OF Clerodendrum paniculatum L. AS A NATURAL HEPATOPROTECTIVE AGENT

Objective: This study investigated whether the root extract of Clerodendrum paniculatum L. is effective as a hepatoprotective agent in rat models. Methods: The experiment utilized Wistar rats randomly assigned to five groups and treated with either paracetamol (2 g/kg, p.o.) or CCl₄ (0.7 ml/kg, i.p.) to induce hepatotoxicity. Test groups received Clerodendrum paniculatum root extract at doses of 200 mg/kg and 400 mg/kg, while a standard group received silymarin (25 mg/kg, p.o.). Liver function was assessed through biochemical markers— ALT, AST, ALP, and total bilirubin. Histopathological analysis of liver tissues was also performed. Results: Rats treated with the extract showed a significant, dose-dependent decrease in ALT, AST, ALP, and total bilirubin levels compared to toxic controls. The 400 mg/kg dose exhibited effects nearly comparable to silymarin. Histology confirmed reduced necrosis, inflammation, and fatty changes in liver tissue, indicating structural recovery. Preliminary phytochemical analysis revealed the presence of flavonoids, alkaloids, and tannins, supporting the extract’s antioxidant potential. Conclusion: Our results suggest that Clerodendrum paniculatum L. root extract offers substantial protection against liver toxicity, making it an effective natural agent against liver injury.