Chlorjaponoids A and B, Two Lindenane–Guaiane Sesquiterpenoid Dimers with a Cage-like Tetracyclo[8.5.0.0 <sup>2,7</sup> .0 <sup>3,13</sup> ]pentadecane Scaffold from <i>Chloranthus japonicus</i>
Two heterodimeric sesquiterpenoids, chlorjaponoids A (<b>1</b>) and B (<b>2</b>), were isolated from the whole plants of <i>Chloranthus japonicus</i>. Their structures, characterized by a unique cage-like tetracyclo[8.5.0.0<sup>2,7</sup>.0<sup>3,13</sup>]pentadecane scaffold, were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction. Both compounds demonstrated antihepatic fibrosis activity in vitro.
Authors
- Rao Huang (ORCID: https://orcid.org/0000-0001-9913-2123)
- Xinyi Hu
- Lu Gan (ORCID: https://orcid.org/0000-0003-1056-7660)
- Li-Fen Ma
- Dean Guo
- Wei Li
Institutions
- Sun Yat-sen University (CN)
- Shanghai Institute of Materia Medica (CN)
- Southern Medical University (CN)
- Academia Sinica (TW)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c05428
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00