Downregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts
Ethanol disrupts circadian signaling and enhances profibrotic gene expression in lung fibroblasts, partly through suppression of RORα. RORα activation mitigates these effects, identifying RORα as a potential therapeutic target for ethanol-related maladaptive lung repair.
Authors
- Kenkichi Baba (ORCID: https://orcid.org/0000-0002-7697-3170)
- Hui Tao
- Samantha M. Yeligar (ORCID: https://orcid.org/0000-0001-9309-0233)
- Gianluca Tosini (ORCID: https://orcid.org/0000-0003-3645-4533)
- Nicolás M. Díaz
- Viranuj Sueblinvong
- Xian Fan
- Justin Guo
- Bum-Yong Kang
Institutions
- Cystic Fibrosis Foundation (US)
- Pulmonary and Allergy Associates (US)
- Atlanta VA Health Care System (US)
- Morehouse School of Medicine (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fmed.2026.1719787
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism