Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Panx1 inhibition (<i>via</i> PBC) suppresses the HIF-1α/VEGF signaling pathway and reduces hypoxia-induced endothelial cell proliferation, providing a novel preventive strategy for ROP.

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Publication Details

Journal
Current Eye Research
Published
2026-02-04
DOI
https://doi.org/10.1080/02713683.2026.2621957
Primary Topic
Retinal Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Chuan Hui Nie, Y. Zhang, Nan Yao, Yajing Chen et al.
Current Eye Research
Retinal Diseases and Treatments
article

Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Chuan Hui Nie, Y. Zhang, Nan Yao, Yajing Chen, Meng Li, Guanwei Shen, Shuting Yu
article en

Abstract

Panx1 inhibition (<i>via</i> PBC) suppresses the HIF-1α/VEGF signaling pathway and reduces hypoxia-induced endothelial cell proliferation, providing a novel preventive strategy for ROP.

Current Eye Research
Women's and Children's Hospital (AU), Guangdong Province Women and Children Hospital (CN), Fo Guang University (TW)
Good health and well-being
Openalex Percentile: Top 67%
Retinal Diseases and Treatments
DOISourceOpenAlex
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