Childhood chronic stress associated with abnormal brain white matter networks in first-episode, drug-naïve MDD adolescents: a machine learning study
We found that chronic childhood stress is associated with local topological abnormalities in multiple regions of the white matter structural networks of adolescents with MDD. These altered white matter network topological properties may be utilized in the future to aid in identifying depressive subtypes with high childhood stress exposure.
Authors
- Shoukang Zou (ORCID: https://orcid.org/0009-0002-7667-9016)
- Meijiang Jin (ORCID: https://orcid.org/0009-0000-2914-441X)
- Hanmei Xu
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- Lixue Yin (ORCID: https://orcid.org/0000-0002-9007-1800)
- Maojia Ran
- Yuanmei Tao
- Zhaoxian Ming
- Ye Wu
- Hang Zhang
Institutions
- Sichuan University (CN)
- Nanjing University of Science and Technology (CN)
- West China Hospital of Sichuan University (CN)
- Frontier Science Foundation (CH)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fpsyt.2026.1732661
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Health Commission of Sichuan Province