C-Type Natriuretic Peptide Preserves Vascular and Cardiac Function in Sepsis
Endogenous CNP plays a protective role in sepsis by preserving microvascular perfusion, reducing inflammation, maintaining endothelial integrity, and sustaining cardiac function via NPR-C. Pharmacologically targeting CNP signaling warrants further evaluation as a potential therapeutic opportunity in sepsis.
Authors
- Aisah A. Aubdool (ORCID: https://orcid.org/0000-0002-4712-9421)
- Reshma S. Baliga (ORCID: https://orcid.org/0000-0002-5582-5152)
- Aemun T. Salam (ORCID: https://orcid.org/0000-0002-8066-8101)
- Gordon Ac
- Claire A. Sand (ORCID: https://orcid.org/0000-0001-7293-4070)
- Adrian J. Hobbs (ORCID: https://orcid.org/0000-0002-3589-7108)
- Sandy M. Chu
- Shireen Mohammad
- Cristina Perez-Ternero
- Leanne Young
- David B. Antcliffe
Institutions
- Queen Mary University of London (GB)
- William Harvey Research Institute (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Hypertension
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25938
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00