ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma
ZNF395 and HIF are complementary mediators of hypoxia-induced metabolic reprogramming and therapeutic targets in VHL-deficient kidney cancer, with the former regulating glutamine metabolism and the latter regulating glucose metabolism.
Authors
- Heng Hl
- Lye Siang Lee
- Jing Han Hong (ORCID: https://orcid.org/0000-0002-2173-9192)
- Dan Y. Gui (ORCID: https://orcid.org/0009-0003-9976-6435)
- Kevin Lim (ORCID: https://orcid.org/0000-0002-3822-1242)
- Gertrud Steger (ORCID: https://orcid.org/0000-0002-0581-8122)
- Z. Li
- Radoslaw M. Sobota (ORCID: https://orcid.org/0000-0002-2455-2526)
- Michelle Ng (ORCID: https://orcid.org/0000-0001-5113-3733)
- Jianhong Ching
- Jabed Iqbal (ORCID: https://orcid.org/0000-0003-4137-1791)
- Xiaosai Yao (ORCID: https://orcid.org/0000-0001-9729-0726)
- Zhenxun Wang (ORCID: https://orcid.org/0000-0002-7862-4636)
- Joanna Koh
- Bin Tean Teh
- Benjamin Yan-Jiang Chua
- Qing Zhang
- Ralph J. DeBerardinis
- Divya Bezwada
Institutions
- Agency for Science, Technology and Research (SG)
- Howard Hughes Medical Institute (US)
- Singapore General Hospital (SG)
- Texas Oncology (US)
- KK Women's and Children's Hospital (SG)
- Dana-Farber Cancer Institute (US)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- University Hospital Cologne (DE)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4745
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00