PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition
These findings demonstrate that pH-sensitive AKNPs integrate stromal remodeling and metabolic inhibition to synergistically suppress PDAC progression. This nanoplatform provides a promising therapeutic strategy for overcoming stromal and metabolic barriers in pancreatic cancer and may serve as a foundation for future combination regimens.
Authors
- Yuzhe Xue (ORCID: https://orcid.org/0009-0007-2252-1762)
- Jiaqi Yu (ORCID: https://orcid.org/0009-0004-2128-0109)
- Xiaojing Liu (ORCID: https://orcid.org/0000-0002-9712-2324)
- Yuanmin Hu
- Xuesong He
- Fenfen Jiang
Institutions
- Zhejiang Chinese Medical University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fphar.2026.1723694
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province