Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
This study demonstrates that common CYP2B6 variants alter testosterone metabolism in a human breast cancer model, potentially disrupting steroid hormone balance and contributing to a tumour-promoting environment. These findings highlight the potential relevance of pharmacogenetic profiling in breast cancer risk assessment.
Authors
- Stefan Düsterhöft (ORCID: https://orcid.org/0000-0002-6926-136X)
- Julian Peter Müller (ORCID: https://orcid.org/0009-0002-1505-5664)
- Sabrina Yamoune
- Katja Susanne Just (ORCID: https://orcid.org/0000-0002-6782-8078)
- Marco Hoffmann
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1002/bcp.70473
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00