Greener Approaches towards <i>α</i> ‐Brominated Enolizable Ketones: Needs, Importance, Mechanistic, and Sustainable Perspective

ABSTRACT α‐ Bromocarbonyl compounds have been proven to be an important class of precursors for a wide variety of compounds. Most previously reported methods involve the use of hazardous chemicals, harsh reaction conditions, and the generation of other halogenated impurities. Owing to their versatile nature, substantial studies have been conducted on α‐ bromination of enolizable ketones with high selectivity under mild, efficient, and easy‐ to‐ work reaction conditions. In recent years, scientists have focused on enhancing the sustainability, effectiveness, and versatility of the synthetic protocols. This review critically describes the ionic, radical, electrochemical, and catalytic pathways in α‐ bromination reactions, comparing the influence of regioselectivity and reaction efficiency, along with mechanistic aspects, highlighting the greener advancements made over the past 20 years associated with α‐ bromination of enolizable ketones.