Negative life events and emotional symptoms from ages 2 to 30 years

Importance Exposure to different types of negative life events, including traumatic events, is common across the lifespan and associated with increased mental health symptoms. Objective To assess whether vulnerability to negative life events varies across 5 developmental periods from preschool to young adulthood. Design, Setting, and Participants This cohort study analyzed data from 3 community-representative studies set in the southeastern US (1992-2015) with harmonized assessment approaches that included a total of 13 775 assessments of individuals aged 2 to 30 years with up to 21 years of follow-up. Data analysis occurred from July 2023 to June 2024. Exposures Each study assessed lifetime exposure to (1) traumatic events (ie, severe events associated with posttraumatic stress disorder) and (2) recent stressful events (eg, loss of a friend or moving). All assessments were completed with structured interviews with participants and/or their caregivers. Main Outcomes and Measures The primary outcome was emotional symptoms (ie, anxiety and depressive symptoms). Associations of both categories of life events with emotional symptoms were compared across preschool (<7 years), childhood (7-12 years), adolescence (13-17 years), late adolescence (18-22 years), and young adulthood (23-30 years). Results Analyses were based on 13 775 assessments of 3258 participants (1519 female [weighted percentage, 50.0%]). Recent stressful events were associated with emotional symptoms across each developmental period, ranging from a low in preschool (B =0.14; SE = 0.05) to a high in young adulthood (B = 0.57; SE = 0.12) in cross-sectional analyses and ranging from a low in childhood (B = 0.10; SE = 0.06) to a high adolescence (B = 0.19; SE = 0.05) in longitudinal analyses. Lifetime traumatic events were associated with emotional symptoms across each developmental period, ranging from a low in preschool (B = 0.18; SE = 0.05) to a high in adolescence (B = 0.28; SE = 0.04) in cross-sectional analyses and ranging from a low in childhood (B = 0.09; SE = 0.06) to a high in late adolescence (B = 0.21; SE = 0.05) in longitudinal analyses. Associations had overlapping 95% CIs across the different developmental periods with one exception: stressful events had a larger-magnitude cross-sectional association with emotional symptoms in young adulthood than in other developmental periods. Results were consistent with additive, rather than interactive, associations of traumatic and stressful events with emotional symptoms at each developmental period. Conclusions and Relevance In this cohort study of 3 community-representative samples, vulnerability to traumatic and stressful events was generally similar across the first 3 decades of life; both types of events had an independent association with emotional functioning. These findings suggest response to stressful events is similar from childhood to adulthood.