Comparative Effectiveness of Disease-Modifying Treatments in Double Seronegative Neuromyelitis Optica Spectrum Disorder
This study provides Class IV evidence that, in patients with DS-NMOSD, treatment with a DMT reduces relapse incidence rate ratio compared with no treatment and anti-CD20 DMTs are associated with a lower relapse incidence rate ratio compared with nonspecific immunosuppressants.
Authors
- Marina Solti
- Emily Gibbons (ORCID: https://orcid.org/0000-0003-0470-1499)
- Saif Masharil Huda
- D. Callegaro
- Viviane Tavares Carvalho Crelier
- Jonathan D. Krett (ORCID: https://orcid.org/0000-0003-4964-3341)
- João Vitor Mahler (ORCID: https://orcid.org/0000-0002-0700-3517)
- Sasitorn Siritho (ORCID: https://orcid.org/0000-0002-2562-697X)
- Natalia Drosu
- Radhika Vij
- Yana Said (ORCID: https://orcid.org/0009-0004-4350-1910)
- Rebecca L. Gillani (ORCID: https://orcid.org/0000-0002-4510-1740)
- A. H. Kim
- Giovanna S. Manzano (ORCID: https://orcid.org/0000-0002-9991-9222)
- Ekdanai Uawithya (ORCID: https://orcid.org/0009-0008-6262-8158)
- Gerome Vallejos (ORCID: https://orcid.org/0000-0001-6006-3909)
- Bruna Leles Vieira de Souza
- Ahmetcan Sezen (ORCID: https://orcid.org/0009-0007-6078-0423)
- Manisha Ramprasad
- Olivia Pasquale
- Guilherme Diogo Silva
- Ilya Kister
- Philippe Bilodeau
- Samira Luisa Apóstolos-Pereira
- Natasha Bobrowski-Khoury
- Takahisa Mikami
- Elias Sotirchos
- Ayse Altintas
- Monique Anderson
- Michael Levy
- Hesham Abboud
- Gutemberg dos Santos
- Yanjun Guo
- Anu Jacob
- Marcelo Matiello
- Feng Gai (ORCID: https://orcid.org/0009-0004-2947-0660)
Institutions
- Creighton University (US)
- Brigham and Women's Hospital (US)
- Beijing Tongren Hospital (CN)
- Siriraj Hospital (TH)
- Koç University (TR)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Liverpool (GB)
- Universidade Federal Fluminense (BR)
- Capital Medical University (CN)
- University Hospitals of Cleveland (US)
- Johns Hopkins Medicine (US)
- Walton Centre (GB)
- Massachusetts General Hospital (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- University School (US)
- New York University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1212/nxi.0000000000200514
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 36.00