<scp>WDR72</scp> Is Required for Urinary Acidification and Normal H <sup>+</sup> ‐ <scp>ATPase</scp> Activity in Intercalated Cells in Mice
These findings identify WDR72 as a critical regulator of type A-intercalated cell dependent urinary acidification, modulating H<sup>+</sup>-ATPase activity. The sex-specific metabolic phenotype reveals a novel mechanism underlying sex differences in renal acid handling.
Authors
- Carsten A. Wagner (ORCID: https://orcid.org/0000-0002-9874-8898)
- Hannah Auwerx
- Xiaoxu Li (ORCID: https://orcid.org/0000-0001-5121-9190)
- Soline Bourgeois (ORCID: https://orcid.org/0009-0009-1492-4558)
- Moana Busch‐Dohr
Institutions
- University of Zurich (CH)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1111/apha.70165
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Universität Zürich