Efficient Detection of Esomeprazole Magnesium Using Self‐Assembled Supramolecular of Chiral Dicyanovinylene End‐Capped H ₈ ‐BINOL With AIE Properties

Various benzene and heterocyclic structures could be connected to both 3,3'-positions of H₈-BINOL by Suzuki coupling reactions. The dihedral Angle of H₈-BINOL was reduced by the electron-withdrawing groups on the benzene ring, and the dihedral angle was smaller with stronger electron-absorbing ability. Dicyanovinylenes end-capped H₈-BINOL derivatives R1 have good aggregation-induced emission (AIE) properties and bright yellow fluorescence. The single crystal diffraction pattern manifested that R1 molecules exhibited curved ends and could self-assemble into boat-like structures with much smaller dihedral angle of 73.23°. It was attributed to the formation of molecular torsion due to the electron-withdrawing properties of -CN. The morphology characterization of R1 could self-assemble into nanospheres in ethanol solution. The results of fluorescence properties of R1 were shown as follows: 1. In DMSO/H₂O system with different proportions, R1 had AIE effect, which was attributed to the electron-withdrawing effect of propyl dicyanide. The fluorescence is strongest when the water content is 70%. 2. R1 had obvious fluorescence quenching for esomeprazole magnesium and exhibited a low detection limit (LOD = 1.23 × 10^-9 M), which indicated that the novel fluorescent probe had a good guiding effect on the recognition of chiral drug.