The impact of chemotherapy on floating vs. attached colorectal cancer cells: An in-vitro study
Chemotherapy administered to cancer cells prior to full surface adhesion strongly impairs cancer cell adhesion, growth, and expansion. This phenomenon may partly explain the favorable clinical outcomes observed with (neo)adjuvant chemotherapy before and after complete cancer resection in PM and other cancer types. Floating cells seem to be more sensitive to chemotherapeutic agents than attached cells. Delaying and targeting specifically the ability of cancer cells to attach could help enormously in the treatment of many cancer manifestations such as PM. Further research is needed to confirm these findings in other cancer entities and to explore their potential clinical applications.
Authors
- Veria Khosrawipour (ORCID: https://orcid.org/0000-0003-4575-823X)
- Kacper Zielinski
- Wojciech Kielan
- Carolina Khosrawipour
- Zdzisław Kiełbowicz (ORCID: https://orcid.org/0000-0003-4946-0449)
- Zhiwen Zhang (ORCID: https://orcid.org/0000-0002-0797-9448)
- Agata Mikołajczyk-Martinez
- Patrycja Salata
- Mouhamed El-Aita
- Shiri Li
- Wolfram T. Knoefel
- Kamila Kuzniak
- Jacek Bania
- Ewa Nicpon
- Przemyslaw Przadka
Institutions
- Cedars-Sinai Medical Center (US)
- Wrocław University of Environmental and Life Sciences (PL)
- Wroclaw Medical University (PL)
- Düsseldorf University Hospital (DE)
- Samuel S. Fleisher Art Memorial (US)
- Ministry of Education (KR)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fonc.2026.1697776
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00