TCR β CDR3 repertoire remodeling in pediatric myocarditis reveals clonal expansion and disease-associated public clonotypes
Our study demonstrates distinct repertoire remodeling in pediatric myocarditis, characterized by reduced diversity, skewed V/J gene usage, biased CDR3 composition, and enriched public clonotypes. These findings provide novel insights into disease-related adaptive immune responses and may inform biomarker discovery for diagnosis and therapeutic strategies.
Authors
- Yanfei Chen
- Xixiong Lin
- Zhongjian Su
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Xingzhu Liu (ORCID: https://orcid.org/0000-0002-2237-261X)
- Bin Li
- Liping Zhang
- Xing Zhang
- Linhu Hui
Institutions
- Zunyi Medical University (CN)
- Kunming Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1711681
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education