A treat‐to‐target approach for obesity management: A post hoc analysis of the <scp>SURMOUNT</scp> ‐5 trial

In this post hoc analysis of SURMOUNT-5, most participants who reached the proposed TtT thresholds achieved the goal of low disease activity to remission defined by cardiometabolic risk parameters. These data suggest that TtT thresholds in obesity medicine may clarify goals in shared decision-making and improve clinical outcomes.

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Journal
Diabetes Obesity and Metabolism
Published
2026-02-03
DOI
https://doi.org/10.1111/dom.70531
Primary Topic
Bariatric Surgery and Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

A treat‐to‐target approach for obesity management: A post hoc analysis of the SURMOUNT ‐5 trial

Georgios K. Dimitriadis, Beverly L. Falcón, Çağrı Şenyücel, Luca Busetto et al.
Diabetes Obesity and Metabolism
Bariatric Surgery and Outcomes
article

A treat‐to‐target approach for obesity management: A post hoc analysis of the SURMOUNT ‐5 trial

Georgios K. Dimitriadis, Beverly L. Falcón, Çağrı Şenyücel, Luca Busetto, Deborah B. Horn, Julia P. Dunn, Elisa Gomez Valderas, Luis‐Emilio Garcia‐Perez, Theresa Hunter Gibble, Carel W. le Roux, Louis Aronne
article en

Abstract

In this post hoc analysis of SURMOUNT-5, most participants who reached the proposed TtT thresholds achieved the goal of low disease activity to remission defined by cardiometabolic risk parameters. These data suggest that TtT thresholds in obesity medicine may clarify goals in shared decision-making and improve clinical outcomes.

Diabetes Obesity and MetabolismVol. 28(4)
University College Dublin (IE), University of Padua (IT), University of Ulster (GB), Eli Lilly (United States) (US), Cornell University (US), The University of Texas Health Science Center (US)
Eli Lilly and Company
Good health and well-being
Openalex Percentile: Top 67%
Bariatric Surgery and Outcomes
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A treat‐to‐target approach for obesity management: A post hoc analysis of the <scp>SURMOUNT</scp> ‐5 trial — Georgios K. Dimitriadis, Beverly L. Falcón, et al. · Diabetes Obesity and Metabolism (2026) | TGRS Research Map | TGRS