Identification and validation of biomarkers of Shenggu Zaizao Wan in the treatment of steroid-induced osteonecrosis of the femoral head by integrating network pharmacology and bulk transcriptomic

This study identified IKBKB and PRKCA as potential biomarkers and targets for SZW treatment in SONFH.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-02-04
DOI
https://doi.org/10.3389/fmed.2026.1732825
Primary Topic
Bone and Joint Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Identification and validation of biomarkers of Shenggu Zaizao Wan in the treatment of steroid-induced osteonecrosis of the femoral head by integrating network pharmacology and bulk transcriptomic

Jinqiu Wu, X P Zhang, Qingsheng Xie, Tao Ma et al.
Frontiers in Medicine
Bone and Joint Diseases
article

Identification and validation of biomarkers of Shenggu Zaizao Wan in the treatment of steroid-induced osteonecrosis of the femoral head by integrating network pharmacology and bulk transcriptomic

Jinqiu Wu, X P Zhang, Qingsheng Xie, Tao Ma, Jianjun Liu, Yin Li, Xianfu Han, Duoxian Wang, Xuerui Liu, Hairong He, Haiyang Yu, Jinpeng Wang, Lingwei Yuan
article en

Abstract

This study identified IKBKB and PRKCA as potential biomarkers and targets for SZW treatment in SONFH.

Frontiers in MedicineVol. 13
Gansu University of Traditional Chinese Medicine (CN), Shenzhen Bao'an District People's Hospital (CN)
Openalex Percentile: Top 68%
Bone and Joint Diseases
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