Global clinical trial landscape of stem cell-based therapies for osteoarthritis: trends and translational implications
The number of stem cell-based clinical trials for osteoarthritis is increasing globally, but heterogeneity in study designs and incomplete public reporting limit reliable conclusions about efficacy. Future research should prioritize standardizing products and protocols, employing more rigorous comparators and feasible blinding, extending follow-up periods, and ensuring transparent reporting to facilitate clinical translation.
Authors
- Long Cheng (ORCID: https://orcid.org/0000-0002-7084-5821)
- Yue Zhao (ORCID: https://orcid.org/0000-0001-8983-0024)
- Dongsheng Guo (ORCID: https://orcid.org/0000-0002-2123-8398)
- Yuefu Dong
- Chen Yan
- Xin Li
- Jian Zhang
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Lianyungang Maternal and Children’s Hospital (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fcell.2026.1757935
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University