Clinical characteristics of pulmonary non-tuberculous mycobacterial disease with <i>CFTR</i> variants in the Japanese population
We defined the frequency and clinical characteristics of <i>CFTR</i> variants among the Japanese population with either pulmonary NTM disease, non-cystic fibrosis bronchiectasis or both and found that patients with <i>CFTR</i> variants may be refractory to pulmonary <i>Mycobacterium avium</i> complex disease. Further comprehensive research is needed to assess the impact of <i>CFTR</i> variants on pulmonary NTM disease and bronchiectasis in non-European populations.
Authors
- Ho Namkoong
- A. Morita
- Fuyuki Miya
- Naoki Fukunaga
- K. Nakagawara
- Hirofumi Kamata
- Steven M Holland
- Hiromu Tanaka
- Tomoyasu Nishimura
- Masanori Kaji
- Koichi Fukunaga
- Akemi Hara
- Takanori Asakura
- Shuhei Azekawa
- Naoki Hasegawa
- Genta Nagao
Institutions
- Keio University (JP)
- National Institute of Allergy and Infectious Diseases (US)
- Kitasato University (JP)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/bmjresp-2025-003683
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science