Functionally Characterizing the Renal Cell Carcinoma Tumor-Immune Microenvironment via Patient-Derived <i>Ex Vivo</i> Models
We developed a patient-derived ex vivo model to study immune cell therapy responses within the TME of RCC. Immune activation toward PD-1 blockade and VEGFRi was attenuated and depended on the immune cell state.
Authors
- Anita Kumari
- Anna Kreutzman (ORCID: https://orcid.org/0000-0002-5587-8844)
- Riikka Järvinen (ORCID: https://orcid.org/0000-0001-6182-9793)
- Karita Peltonen (ORCID: https://orcid.org/0000-0002-3063-451X)
- Tuomas Mirtti (ORCID: https://orcid.org/0000-0003-0455-9891)
- Jason Theodoropoulos (ORCID: https://orcid.org/0000-0002-2399-658X)
- Kanerva Lahdensuo (ORCID: https://orcid.org/0000-0003-0510-3546)
- Sara Tornberg (ORCID: https://orcid.org/0000-0002-9666-2126)
- Johannes Smolander (ORCID: https://orcid.org/0000-0003-3872-9668)
- Hanna Laitinen (ORCID: https://orcid.org/0009-0008-7505-5512)
- Heidi M. Haikala (ORCID: https://orcid.org/0000-0002-8465-8568)
- Jay Klievink (ORCID: https://orcid.org/0000-0002-4081-5840)
- Linh Lin (ORCID: https://orcid.org/0009-0003-3040-062X)
- Junhao Liu (ORCID: https://orcid.org/0009-0007-3694-7799)
- Satu Mustjoki
- Neja Sirc
- Moon Hee Lee
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Finnish Cancer Registry (FI)
- Cancer Society of Finland (FI)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0447
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00