De novo protein design: a transformative frontier in clinical protein applications
Despite notable methodological progress in de novo protein design, its path toward clinical application continues to be limited by a range of biological, technical, and translational considerations. Future work will need closer coordination between computational design, experimental validation, engineering optimization, and clinical needs, with clinical feasibility considered early and refined throughout development.
Authors
- Jie Gao (ORCID: https://orcid.org/0000-0003-3330-2219)
- Zaiyong Zheng (ORCID: https://orcid.org/0000-0003-4731-1829)
- Yamei Luo (ORCID: https://orcid.org/0009-0003-5937-3346)
- Xueting Yu
- Chunxiang Zhang
- Yang Yu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Panzhihua Central Hospital (CN)
- Jiangjin Central Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12967-026-07784-0
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00