Medial prefrontal activation as a neural predictor of cognitive training gains in older adults with amnestic mild cognitive impairment: exploratory evidence

The findings suggest that increased medial prefrontal activation during attentional training reflects compensatory engagement and task-related control processes, which in turn predict larger cognitive gains in individuals with aMCI. These results indicate that neural activation measured during training can serve as a reliable predictor of subsequent cognitive gains, offering a potential foundation for designing personalized and adaptive educational programs.