Potent antitumor activity through dual targeting of PD-L1 and TGF-β pathways in the glioma tumor microenvironment
Our findings provide strong support for the combined targeting of TGF-β and PD-L1 as a promising immunotherapeutic strategy to overcome immunosuppressive barriers in glioblastoma and induce potent antitumor responses.
Authors
- B. Becher
- Nicolás Gonzalo Núñez (ORCID: https://orcid.org/0000-0003-3837-270X)
- Kienzler JC
- Maximilian Mastall
- Michael Weller
- Manuela Silginer
- Patrick Roth
- Tobias Weiss
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/jitc-2025-011824
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00