Cooperation between HIV-1 integrase natural polymorphism K156N and 3′PPT mutations in dolutegravir monotherapy failure
These findings establish a direct functional relationship between natural variation in HIV-1 integrase and the emergence of 3'PPT mutations. People harbouring a virus with the K156N natural polymorphism may be predisposed to developing 3'PPT mutations upon failure with DTG. However, the clinical relevance of this association remains to be established.
Authors
- Thibault Mésplède (ORCID: https://orcid.org/0000-0003-0515-9128)
- Rob A. Gruters (ORCID: https://orcid.org/0000-0002-8486-5903)
- Ronald J. Overmars (ORCID: https://orcid.org/0000-0002-8984-0633)
- Rizwan Mahmud
- Alicja Górska
- Alessia David (ORCID: https://orcid.org/0000-0001-8687-024X)
- Jérôme Cornette (ORCID: https://orcid.org/0000-0001-8482-5138)
- Zoë Krullaars (ORCID: https://orcid.org/0000-0001-8430-0411)
- Mike Voskamp
- Cynthia Lungu
- Ehikioya Azugbene
- Alicia B H Cromme
- Jolieke A T van Osch
- Jolanda J C Voermans
- Haajar Ouzerne
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1093/jac/dkag033
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Allergy and Infectious Diseases