Synthesizing scientific literature with retrieval-augmented language models
Scientific progress depends on the ability of researchers to synthesize the growing body of literature. Can large language models (LLMs) assist scientists in this task? Here we introduce OpenScholar, a specialized retrieval-augmented language model (LM)<sup>1</sup> that answers scientific queries by identifying relevant passages from 45 million open-access papers and synthesizing citation-backed responses. To evaluate OpenScholar, we develop ScholarQABench, the first large-scale multi-domain benchmark for literature search, comprising 2,967 expert-written queries and 208 long-form answers across computer science, physics, neuroscience and biomedicine. Despite being a smaller open model, OpenScholar-8B outperforms GPT-4o by 6.1% and PaperQA2 by 5.5% in correctness on a challenging multi-paper synthesis task from the new ScholarQABench. Although GPT-4o hallucinates citations 78-90% of the time, OpenScholar achieves citation accuracy on par with human experts. OpenScholar's data store, retriever and self-feedback inference loop improve off-the-shelf LMs: for instance, OpenScholar-GPT-4o improves the correctness of GPT-4o by 12%. In human evaluations, experts preferred OpenScholar-8B and OpenScholar-GPT-4o responses over expert-written ones 51% and 70% of the time, respectively, compared with 32% for GPT-4o. We open-source all artefacts, including our code, models, data store, datasets and a public demo.
Authors
- Sergey Feldman (ORCID: https://orcid.org/0000-0003-0386-0922)
- Pan Ji
- Minyang Tian (ORCID: https://orcid.org/0000-0001-8009-9116)
- Rulin Shao
- Jacqueline He
- Yanyu Xiong (ORCID: https://orcid.org/0000-0002-4399-6253)
- Kyle Shih-Huang Lo (ORCID: https://orcid.org/0000-0002-0338-6469)
- Luca Soldaini (ORCID: https://orcid.org/0000-0001-6998-9863)
- Shengyan Liu (ORCID: https://orcid.org/0000-0003-0582-7085)
- Bohao Wu (ORCID: https://orcid.org/0000-0003-0128-8459)
- Joseph Chee Chang (ORCID: https://orcid.org/0000-0002-0798-4351)
- Amanpreet Singh (ORCID: https://orcid.org/0000-0001-5980-7608)
- Daniel S. Weld
- Akari Asai
- Doug Downey
- Varsha Kishore
- David Wadden
- Wen-tau Yih
- Pang Wei Koh
- Hao Tong
- Graham Neubig
- Jenna Sparks
- Jena D. Hwang
- Hannaneh Hajishirzi
- Weijia Shi
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Illinois Urbana-Champaign (US)
- University of Washington (US)
- Allen Institute (US)
- Carnegie Mellon University (US)
- Stanford University (US)
Publication Details
- Journal
- Nature
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1038/s41586-025-10072-4
- Citations
- 4
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 53.11
Funders
- National Research Foundation
- National Research Foundation Singapore