Distinct Trajectories of Symptom Burden Development in Patients With Stage IV Cancer
Approximately one-third of patients with stage IV cancer are at risk of high symptom burden. Our study identified distinct patient profiles that can be used to proactively identify those at increased risk. Timely identification of these patients using symptom monitoring allows clinicians to optimize timely and adequate treatment of coexisting symptoms. These findings highlight the importance of personalized approaches in improving health-related quality of life for patients with advanced cancer.
Authors
- Anna K.L. Reyners (ORCID: https://orcid.org/0000-0003-1678-7816)
- Heidi P. Fransen (ORCID: https://orcid.org/0000-0002-2286-3806)
- Cornelia A. Verberkt (ORCID: https://orcid.org/0000-0002-5693-1256)
- Iris Walraven
- Albert H de Heij (ORCID: https://orcid.org/0000-0002-8085-3358)
- N. Billingy (ORCID: https://orcid.org/0000-0002-3590-4961)
- Corina J.G. van den Hurk
- Natasja J.H. Raijmakers
- Annemarie Becker-Commissaris
- Yvette M. van der Linden
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Radboud University Medical Center (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Pain and Symptom Management
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jpainsymman.2026.01.022
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Kwaliteitsgelden Medisch Specialisten