Emergence and characterization of a novel ST627-KL8 carbapenem-resistant Klebsiella pneumoniae lineage associated with ICU transmission in a tertiary hospital, China
This study identified a novel ST627-KL8 CRKP clone with intermediate virulence, consistent with its reduced capsule phenotype and lack of classical hypervirulence genes. These features, together with the subtle clinical presentations, may contribute to reduced clinical vigilance and delayed optimization of antimicrobial therapy. Importantly, ST627-KL8 CRKP carried the IncFII<sub>K34</sub> <i>bla</i> <sub>KPC-2</sub> plasmid, which has been reported to exhibit high conjugation frequency, posing a significant challenge in clinical settings.
Authors
- Guoxin Xu
- Yu Zheng (ORCID: https://orcid.org/0009-0007-5767-2771)
- Hong Du
- Long Chen
- Wei Zhang
- Xiaoxiao Pang
- Chao Ding
Institutions
- Nanjing Agricultural University (CN)
- Soochow University (CN)
- Zhangjiagang First People's Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fmicb.2025.1723336
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China