Determination of Median Effective Concentration (EC50) of Ropivacaine with Adjuvant Dexmedetomidine When Using the Dural Puncture Epidural Technique for Labor Analgesia: An Up-Down Sequential Allocation Study

For labor analgesia using the DPE technique, 0.3 µg/mL dexmedetomidine is the optimal adjuvant concentration to ropivacaine, balancing analgesic efficacy and safety. Higher concentrations do not enhance analgesia but may increase the risk of sedation.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2026-02-01
DOI
https://doi.org/10.2147/dddt.s571808
Primary Topic
Anesthesia and Pain Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Determination of Median Effective Concentration (EC50) of Ropivacaine with Adjuvant Dexmedetomidine When Using the Dural Puncture Epidural Technique for Labor Analgesia: An Up-Down Sequential Allocation Study

Xin Wang, Jie Zhang, Jianwen Shi, Yang Zhao et al.
Drug Design Development and Therapy
Anesthesia and Pain Management
article

Determination of Median Effective Concentration (EC50) of Ropivacaine with Adjuvant Dexmedetomidine When Using the Dural Puncture Epidural Technique for Labor Analgesia: An Up-Down Sequential Allocation Study

Xin Wang, Jie Zhang, Jianwen Shi, Yang Zhao, Hui Liu
article en

Abstract

For labor analgesia using the DPE technique, 0.3 µg/mL dexmedetomidine is the optimal adjuvant concentration to ropivacaine, balancing analgesic efficacy and safety. Higher concentrations do not enhance analgesia but may increase the risk of sedation.

Drug Design Development and TherapyVol. Volume 20
Qingdao University (CN), Peking University (CN), Affiliated Hospital of Qingdao University (CN), Peking University People's Hospital (CN), Qingdao Eighth People's Hospital (CN), Qingdao Women and Children's Hospital (CN)
Qingdao University
Decent work and economic growth
Openalex Percentile: Top 67%
Anesthesia and Pain Management
DOIOpen Access PDFOpenAlex
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