Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

Our genetics-centred approach quantifies the contribution of obesity to multi-morbidity. Our method for calculating full and partial genetic correlations is published as an R package {partialLDSC}.

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Publication Details

Journal
Communications Medicine
Published
2026-02-04
DOI
https://doi.org/10.1038/s43856-025-01347-y
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00

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article

Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

F Dudbridge, Concepción Violán, Ninon Mounier, Albert Roso‐Llorach et al.
Communications Medicine
Genetic Associations and Epidemiology
article

Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

F Dudbridge, Concepción Violán, Ninon Mounier, Albert Roso‐Llorach, Xiaoran Liang, Mary E. Mancini, C Fox, Leon Farmer, João Delgado, T Frayling, Kate Boddy, Carlos Gallego-Moll, Bethany Voller, Olivia Murrin, Luke Pilling, Linus Tata, Jack Bowden, Ruby M Woodward, David Melzer, Sara Khalid, Lucía A. Carrasco-Ribelles, Sally E. Lamb, Louise M. Allan, Jane A. H. Masoli, Jose M. Valderas
article en

Abstract

Our genetics-centred approach quantifies the contribution of obesity to multi-morbidity. Our method for calculating full and partial genetic correlations is published as an R package {partialLDSC}.

Communications MedicineVol. 6(1)
University of Geneva (CH), Universitat Autònoma de Barcelona (ES), University of Leicester (GB), University of Exeter (GB), Royal Devon & Exeter NHS Foundation Trust (GB), Nuffield Orthopaedic Centre (GB), University of Oxford (GB), Novo Nordisk (Finland) (FI), Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES), Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES), National University Health System (SG)
National Institute for Health and Care Research, Department of Health and Social Care, University of Exeter, Medical Research Council, NIHR Leicester Biomedical Research Centre
Zero hunger
Openalex Percentile: Top 64%
Genetic Associations and Epidemiology
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