Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions
Our genetics-centred approach quantifies the contribution of obesity to multi-morbidity. Our method for calculating full and partial genetic correlations is published as an R package {partialLDSC}.
Authors
- F Dudbridge
- Concepción Violán (ORCID: https://orcid.org/0000-0003-3309-5360)
- Ninon Mounier (ORCID: https://orcid.org/0000-0001-6663-5402)
- Albert Roso‐Llorach (ORCID: https://orcid.org/0000-0002-9264-0405)
- Xiaoran Liang (ORCID: https://orcid.org/0000-0002-2142-2427)
- Mary E. Mancini
- C Fox
- Leon Farmer
- João Delgado (ORCID: https://orcid.org/0000-0003-1648-871X)
- T Frayling
- Kate Boddy (ORCID: https://orcid.org/0000-0001-9135-5488)
- Carlos Gallego-Moll (ORCID: https://orcid.org/0000-0001-7215-4584)
- Bethany Voller
- Olivia Murrin
- Luke Pilling
- Linus Tata
- Jack Bowden
- Ruby M Woodward
- David Melzer (ORCID: https://orcid.org/0000-0003-4188-348X)
- Sara Khalid
- Lucía A. Carrasco-Ribelles
- Sally E. Lamb
- Louise M. Allan
- Jane A. H. Masoli
- Jose M. Valderas
Institutions
- University of Geneva (CH)
- Universitat Autònoma de Barcelona (ES)
- University of Leicester (GB)
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University of Oxford (GB)
- Novo Nordisk (Finland) (FI)
- Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- National University Health System (SG)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1038/s43856-025-01347-y
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Exeter
- Medical Research Council
- NIHR Leicester Biomedical Research Centre