Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia
Thus, properdin was significantly upregulated in the PE placentae, along with C3 and C5, and might be associated with the apoptotic nuclei inside syncytial knots. This evidence suggests that properdin may trigger complement-mediated damage to the placental barrier, exacerbating the development of PE placentae.
Authors
- Chiara Agostinis (ORCID: https://orcid.org/0000-0002-8315-2258)
- Miriam Toffoli
- Uday Kishore (ORCID: https://orcid.org/0000-0002-6033-6759)
- Silvia Pegoraro (ORCID: https://orcid.org/0000-0002-1819-7417)
- Hadida Yasmin (ORCID: https://orcid.org/0000-0001-7292-3937)
- Andrea Balduit (ORCID: https://orcid.org/0000-0001-5902-3205)
- M. Vatish
- Giuseppe Ricci
- Priyanka Sharma (ORCID: https://orcid.org/0000-0003-4841-0650)
- Tamali Roy
- Taruna Madan
- Rajib Prasad
- Aishwarya Rao
- Samik Bindu
- Roberta Bulla
Institutions
- University of Trieste (IT)
- National Institute for Research in Reproductive Health (IN)
- United Arab Emirates University (AE)
- Cooch Behar Panchanan Barma University (IN)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- Indian Council of Medical Research (IN)
- University of Oxford (GB)
- Narayan Medical College and Hospital (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1739327
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 41.10