Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

In this large-scale proteomic study involving 3 longitudinal cohorts of older adults, we identified and replicated 55 novel protein markers of HF or its subtypes, and 7 new, possibly causal proteins. These proteins may enhance risk prediction, improve understanding of pathobiology, and help prioritize targets for therapeutic development of these foremost disorders in elders.

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Journal
Circulation Genomic and Precision Medicine
Published
2026-02-01
DOI
https://doi.org/10.1161/circgen.124.005031
Primary Topic
GDF15 and Related Biomarkers
Type
article
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article

Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

René Fouodjio, Jeffrey Brandimarto, Valborg Guðmundsdóttir, Steven Lubitz et al.
Circulation Genomic and Precision Medicine
GDF15 and Related Biomarkers
article

Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

René Fouodjio, Jeffrey Brandimarto, Valborg Guðmundsdóttir, Steven Lubitz, Albert Henry, Anna Axelsson Raja, Hongsheng Gui, Yunzhang Wang, Finan Chris, Christoffer Rasmus Vissing, Deleuze Jean-Francois, Brandon D. Lowery, Frederick Kamanu, J. B. Wilk, Leonard Buckbinder, Benjamin L. Prosser, Ana M. Valdes, Sean L. Zheng, Brian P. Halliday, Upasana Tayal, V. Salomaa, Douglas Ewan Cannie, Douglass L. Mann, Nicholas Sunderland, Faye Zhao, Sonia Shah, Olympe Chazara, Helen Parry, Charlotte Manisty, Danny Tuckwell, Isabella Kardys, Plagnol, Simon de Denus, Ghazaleh Fatemifar, Heather L. Bloom, Thomas R. Austin, Louis‐Philippe Lemieux Perreault, Yimin Yang, Joyce Njoroge, Diane T. Smelser, Mary L. Biggs, Karl Guo, Peter Weeke, Mark D. Chaffin, Declan P. O’Regan, Stuart A. Cook, Antonio de Marvao, Sahar Ghasemi, Andrea Koekemoer, Andrew D. Morris, Kathryn A. McGurk, Ajay M. Shah, Michelle L. O’Donoghue, Anna Helgadóttir, William A. Chutkow, Kiran J. Biddinger, Ewan R. Pearson, Michael W. Nagle, Géraldine Asselin, Ali Shojaie, Felix Vaura, Harry Hemingway, John Arun Baksi, Johan Ärnlöv, Lars Wallentin, Jian'an Luan, L Jennings, Françoise Fougerousse, Svati Shah, Eric Boersma, Monique Verschuuren, Marcus E Kleber, Uwe Voelker, Steen Stender, N. J. Samani, Doug Speed, Emily Hamerton, Quinn Wells, Chim C. Lang, Jonas Ghouse, Niek Verweij, Markus Perola, Jorge R. Kizer, Mie Topholm Bruun, John J.V. McMurray, Gunnar Engström, Perry M Elliott, Erik Abner, Kent D. Taylor, Bing Yu, Joseph Dowsett, Bruce M. Psaty, Rachel Buchan, Krishna Aragam, Marion van Vugt, Perttu Salo, Mari-Liis Tammesoo, Aroon D. Hingorani, Lavinia Paternoster, Ole Birger Pedersen, J. Wouter Jukema, Trégouët David-Alexandre, Talia Seshaiah, Andrew P. Morris, Christian Erikstrup, Henning Bundgaard, Nisha Bansal, Marcus Dörr, Neneh Sallah, Alaa A. Shalaby, R. Thomas Lumbers, Maryam Kavousi, Michael E. Dunn, Guðmundur Thorgeirsson, Alexander S. Doney, Christopher P. Nelson, Andre G. Uitterlinden, Michael Lee, Ian Ford, Faiez Zannad, Lars Køber, Ruth C. Lovering, Unnur Thorsteinsdottir, Giorgio Melloni, Bitten Aagaard, Vilmundur Gudnason, Lance Adams, Xiao Yan Xu, Christopher M. Haggerty, James S. Ware, Folkert W. Asselbergs, Yi-Pin Lai, Thomas Morgan, Winfried März, Stefan Gross, James P. Cook, Hilma Holm, Mark S. Sabatine, Anjali T. Owens, Catherine Francis, Michael V. Holmes, Michael P. Morley, Joshua D. Backman, Erik Sørensen, Kenneth M. Rice, Thomas A Treibel, Benoit Tyl, Anders Malarstig, Marie Pigeyre, Marie-Pierre Dubé, Yifan Yang, Daníel F. Guðbjartsson, Michael K. Brown, Charlotte Andersson, Peter Almgren, Jaison Jacob, Guillaume Paré, Pantazis I Theotokis;, L. Keoki Williams, Traci M. Bartz, Ify R. Mordi, Olle Melander, Alanna C. Morrison, David Miller, Erik Ingelsson, Bill Kraus, Christian Torp-Pedersen, Jessica van Setten, Laura M. Yerges-Armstrong, Honghuang Lin, Philippe Charron, Karoline Kuchenbaecker, Jonathan H. Chung, Paul J. R. Barton, Christian T. Ruff, Henrik Ullum, Claudia Langenberg, Xing Chen, Nicholas A. Marston, Jerome I. Rotter, Raul Weiss, Lars Lind, Hilary Martin, Samuel C. Dudley, Mahdad Noursadeghi, Sandra Sanders van Wijk, Jing Hua Zhao, Stephan B. Felix, Ramachandran S. Vasan, Sara Hägg, Sisse Rye Ostrowski, Villard Eric, Isabelle Bond, Vilmantas Giedraitis, Raymond Noordam, Kari Stefansson, David van Heel, Michela Noseda, Christoph Nowak;, Sophie Garnier, Colleen M. Sitlani, James C Moon, Mohsen Ghanbari, Hans-Peter Brunner-La Rocca, Jian Yang, Victoria Lamberson, Russell P. Tracy, Lori Morton, Robert E. Gerszten, Dawn Waterworth, Luca A. Lotta, Cecilia M. Lindgren, Harvey L. White, Sundararajan Srinivasan, David J. Carey, Joshua Bis, Hanane Issa, Rebecca Gutmann, Åsa K. Hedman, Sarah Finer, John S. Gottdiener, Jean-Claude Tardif, Craig L. Hyde, Xu Chen, Adriaan A. Voors, Naveed Sattar, Per Svensson, Akshay Shekhar, Barry London, Sanjiv Shah, Kay-Tee Khaw, Daniel I. Chasman, Nicholas J. Wareham, Tõnu Esko, J. Bailey Smith, Hans Hillege, Chaoqun Zheng, Alexander Niessner, Tomasz Czuba, Xiaosong Wang, Søren Brunak, Christopher Newton-Cheh, Jennifer A. Brody, Patrick T. Ellinor, Daniel I. Swerdlow, Paul M. Ridker, Patrik Magnusson, Heming Xing, Simon P. R. Romaine
article en

Abstract

In this large-scale proteomic study involving 3 longitudinal cohorts of older adults, we identified and replicated 55 novel protein markers of HF or its subtypes, and 7 new, possibly causal proteins. These proteins may enhance risk prediction, improve understanding of pathobiology, and help prioritize targets for therapeutic development of these foremost disorders in elders.

Circulation Genomic and Precision MedicineVol. 19(1)
University of Vermont (US), Northwestern University (US), Brigham and Women's Hospital (US), Novartis (Switzerland) (CH), Beth Israel Deaconess Medical Center (US), University of Iceland (IS), Palo Alto University (US), University of Washington (US), Cardiovascular Institute of the South (US), Kidney Research UK (GB), Beth Israel Deaconess Hospital (US), National Institute for Health and Care Research (GB), Cancer Research And Biostatistics (US), Department of Health (TW), Zuyderland Medisch Centrum (NL), Stanford Medicine (US), Health Data Research UK (GB), San Francisco VA Health Care System (US), Northwestern Medicine (US), Icelandic Heart Association (IS), University College London (GB), The University of Texas Southwestern Medical Center (US), The University of Texas Health Science Center at Houston (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 68%
GDF15 and Related Biomarkers
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