Integration host factor regulates antibiotic susceptibility through modulating alanine metabolism in Escherichia coli
Together, these results provide compelling evidence that IHF modulates antibiotic susceptibility through metabolic reprogramming, with alanine metabolism and PMF maintenance serving as key functional links.
Authors
- Huan-zhe Fu
- Hui Li
- Si-chen Yuan
- Ming Jiang
- Yu-Yan Chen
Institutions
- Sun Yat-sen University (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fmicb.2025.1679242
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province