Loss of ROR2 Tyrosine Kinase Receptor Is Associated With Endothelial Dysfunction in PAH via Inappropriate Integrin β1 Activation
ROR2 regulates pulmonary angiogenesis by maintaining endothelial barrier integrity and facilitating integrin recycling. ROR2 restoration could be a potential therapeutic approach for PAH.
Authors
- Ananya Chakraborty (ORCID: https://orcid.org/0000-0003-0974-6370)
- Kwan Man (ORCID: https://orcid.org/0000-0001-5663-6866)
- Eleana Stephanie Guardado
- Prakash Chelladurai (ORCID: https://orcid.org/0000-0002-8258-5115)
- Amanda Pacheco (ORCID: https://orcid.org/0000-0001-7108-2128)
- Natasha Auer (ORCID: https://orcid.org/0000-0002-5573-0356)
- Alexander R. Dunn (ORCID: https://orcid.org/0000-0001-6096-4600)
- Brian L. Zhong (ORCID: https://orcid.org/0000-0001-8818-5692)
- Olivier T. Guenat (ORCID: https://orcid.org/0000-0003-1103-9712)
- Lyong Heo (ORCID: https://orcid.org/0000-0003-4158-9600)
- Wolfgang M. Kuebler
- Dan Yi
- Zhiyu Dai (ORCID: https://orcid.org/0000-0002-0821-2839)
- Jason Hong
- Hanqiu Zhao
- Ramesh Nair
- Arpita Roy
- Anuradha Bankar
- Vinicio A. de Jesus Perez
- Juan Andrés Matos Muñoz
- Stuti Agarwal
- Ananya Jain
Institutions
- University of Bern (CH)
- University of Arizona (US)
- University of California, Los Angeles (US)
- Palo Alto University (US)
- University of Phoenix (US)
- Washington University in St. Louis (US)
- Anna Needs Neuroblastoma Answers (US)
- German Centre for Cardiovascular Research (DE)
- Stanford Medicine (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Stanford University (US)
Publication Details
- Journal
- Hypertension
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25881
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- American Heart Association
- Cleveland Clinic
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- National Heart, Lung, and Blood Institute