LRP8 Promotes colorectal cancer progression by suppressing ferroptosis through the SLC3A2/GPX4 signalling axis
LRP8 facilitates CRC progression by antagonizing ferroptosis via modulation of the SLC3A2/GPX4 signalling axis. These findings highlight LRP8 as a previously unrecognized regulator of ferroptotic vulnerability and a potential therapeutic target in CRC.
Authors
- Chengzhang Zhu (ORCID: https://orcid.org/0000-0001-8825-0992)
- Binbin Du (ORCID: https://orcid.org/0000-0002-1526-635X)
- Yangping Wang (ORCID: https://orcid.org/0000-0002-6226-0460)
- S S Yang
- Xiongfei Yang
- Zhengpeng Qian (ORCID: https://orcid.org/0009-0005-0052-0975)
- Hui Cai
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s40001-026-03964-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Gansu Province
- National Natural Science Foundation of China